Wednesday, October 15, 2025

Exercise, Oxytocin, and Mental Health: A Breakthrough in Stress Relief

Keynote Presentation by Dr. Weina Liu, East China Normal University, China

🧠 Title: Physical exercise activates a PVN-NAc oxytocin circuit to relieve stress-induced depressive-like behaviors

International Conference on Neurology and Neuroscience | March 23–25, 2026 | Singapore & Online


🧠 Key Takeaways from the Presentation

·         💪 Exercise Reduces Depression:
Dr. Weina Liu’s research demonstrates that regular treadmill exercise prevents depressive-like behaviors in stressed mice, highlighting the mood-boosting power of physical activity.

·         🧬 PVN-NAc Oxytocin Circuit:
The study uncovered a novel brain pathway linking the paraventricular nucleus (PVN) to the nucleus accumbens (NAc), where oxytocin signaling plays a critical role in stress resilience.

·         🧠 Neural Activity Restoration:
Four weeks of exercise restored normal neural activity in the NAc, helping maintain motivation and reward processing even under chronic stress.

·         🧫 Oxytocin Receptor Activation:
Microarray analysis revealed significant upregulation of oxytocin receptors, providing molecular insight into how exercise exerts antidepressant effects.

·         🎯 Circuit-Specific Mechanisms:
Activation of the PVN-NAc oxytocin circuit prevented depressive-like behaviors, while its inhibition blocked exercise benefits — proving the circuit’s central role in mood regulation.

·         🌈 Therapeutic Implications:
The findings suggest that targeting the PVN-NAc oxytocin circuit could offer new strategies for treating depression and stress-related disorders.


👩🔬 About Dr. Weina Liu

Dr. Liu is a Changjiang Scholar of China, and serves as Vice Dean of the College of Physical Education and Health at East China Normal University.
She has published over 60 academic papers, including 25 in SCIE/SSCI journals (12 in top-tier journals) and has led more than 10 major research projects funded by national programs.


🌍 Event Details

Event Name: International Conference on Neurology and Neuroscience

📅 Dates: March 23–25, 2026
📍 Venue: Singapore & Online
🌐 Event Website: https://neurocareconference.com/
📩 Email: neurology@mathewsconference.com
📞 Phone: +1 (312) 462-4448 | WhatsApp: +1 (424) 377 0967

📝 Submit Your Abstract: Click Here
🎟Register Now: Click Here


#NeuroscienceConference #MentalHealthResearch #DepressionRelief #ExerciseForMind #OxytocinCircuit #BrainHealth #PVNNAcPathway #NeuroCare2026 #VirtualConference #SingaporeEvents #StressReliefResearch #NeuroscienceInnovation

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