🔬 Research Context
Type 2 diabetes is increasingly recognized as a risk factor for accelerated brain ageing and neurodegeneration. In this presentation, Dr. Tatiana Korolenko highlights how impaired lysosomal function and autophagy contribute to neuronal and glial cell damage, using the db/db mouse model of genetic diabetes as an experimental platform.
Title: Lysosomes, autophagy in brain cells of db/db micewith experimental diabetes
🧪 Inside the Experimental Design
Use of db/db mice representing obesity-linked diabetes
Examination of neurons and glial cells under metabolic stress
Analysis of brain ultrastructure alongside molecular markers
Comparative evaluation between younger and older diabetic animals
⚙️ Testing Trehalose as a Cellular Modulator
Oral administration of 3% trehalose solution for 30 days
Free access to food and water throughout the study
Trehalose assessed for its role as an autophagy-inducing agent
Focus on mTOR-independent pathways affecting brain cells
📊 Key Findings at a Glance
Increased accumulation of lipofuscin, a hallmark of cellular ageing
Trehalose treatment led to:
Reduced obesity and blood glucose levels
Lower neuroinflammation and oxidative stress
Partial improvement in cognitive function
No significant activation of autophagy-related genes (Atg8, Becn1, Park2)
Reduced insulin receptor gene (Insr) expression, indicating altered insulin signaling in the brain
⏳ The Role of Ageing in Therapeutic Response
One of the most important observations was the age-dependent response to trehalose. Younger diabetic mice showed different cellular adaptations compared to older mice, suggesting that ageing limits the effectiveness of autophagy-targeted interventions in the diabetic brain.
🧠 Why These Findings Matter
Strengthens evidence linking diabetes and neurodegenerative disorders
Identifies autophagy decline as a shared pathological mechanism
Highlights the need for early intervention strategies
Provides direction for future neuro-metabolic therapeutic research
👩🔬 About the Scientist
Dr. Tatiana Korolenko is a renowned biochemist and professor at the Scientific Research Institute of Neurosciences and Medicine, Novosibirsk. Her work focuses on lysosomal biology, autophagy, and metabolic brain disorders, with decades of experience mentoring doctoral and postgraduate researchers.
🌍 Join the Global Dialogue at NeuroCare 2026
📅 March 23–25, 2026
📍 Hybrid Event: Singapore & Online
🌐 Website: https://neurocareconference.com/
📝 Abstract Submission: https://neurocareconference.com/abstract-submission
🎟 Register: https://neurocareconference.com/register
#BrainMetabolism #DiabetesAndNeurodegeneration #AutophagyResearch
#Lysosomes #NeuronalHealth #AgeingBrain #NeuroscienceConference #NeuroCare2026
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