🧠 Advancing Alzheimer’s Research: Exploring Potential Disease-Modifying Treatments

Presenter: Tamas Fulop (Université de Sherbrooke, Canada)
Presentation Type: Oral Presentation (Virtual)
Title: Potential disease-modifying treatments for neurocognitive disorders

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🔬 Presentation Highlights

∙ Focus: Investigating innovative therapeutic strategies for Alzheimer's disease, one of the most challenging global neurodegenerative disorders.
∙ Clinical Challenge: Despite recent monoclonal antibody therapies, reliable disease-modifying treatments remain limited.
∙ Research Approach: Evaluation of existing drugs for repurposing in modulating key pathological hallmarks of Alzheimer’s disease.
∙ Drugs Studied: The anti-retroviral drug Raltegravir and SGLT2 inhibitors such as Empagliflozin and Dapagliflozin.
∙ Cellular Models: Experiments conducted using H4 neuroglioma and HMC3 microglia cell models to study molecular alterations induced by amyloid-beta.
∙ Key Findings:

• Raltegravir significantly reduced Tau phosphorylation (p-Tau181) and modulated key kinases and phosphatases.

• Reduced inflammatory signaling through downregulation of the NLRP3 inflammasome pathway.

• SGLT2 inhibitors decreased oxidative stress and neuroinflammatory responses triggered by amyloid-beta.
  ∙ Neuroprotective Effects: Gliflozins improved cell viability and reduced apoptosis in neuronal models.
  ∙ Therapeutic Potential: These findings suggest promising drug-repurposing strategies for modifying disease progression in Alzheimer’s disease.
  ∙ Research Outlook: Provides preliminary mechanistic insights supporting further clinical exploration of these treatments.

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Event: International Conference on Neurology and Neuroscience
📅 March 23–25, 2026
📍 Singapore & Online

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