Presenter: Dr. Annabelle Prosser
Affiliation: Frimley Park Hospital, United Kingdom
Presentation Type: Oral / Poster Presentation (as per scientific
program)
Title: A case of enterovirus rhombencephalitis associated withocrelizumab therapy used to treat multiple sclerosis
🔬 Presentation
Highlights
▪ Clinical Focus: Rare but severe opportunistic
infection linked to B-cell–depleting therapy in relapsing–remitting multiple
sclerosis (RRMS).
▪ Therapeutic Context: Ocrelizumab—an anti-CD20 monoclonal
antibody—commonly used to reduce immune-mediated CNS damage in MS.
▪ Case Insight: A woman in her 40s on ocrelizumab presenting with
vertigo, dysarthria, rigidity, and progressive bulbar dysfunction.
▪ Diagnostic Challenge: Initial investigations inconclusive; definitive
diagnosis achieved through MRI findings and CSF enterovirus PCR.
▪ Neurological Complication: Development of post-encephalitic
parkinsonian syndrome confirmed via EMG and DaT imaging.
▪ Management Strategy: Prolonged antiviral therapy, IV immunoglobulin,
and steroids leading to partial neurological recovery.
▪ Clinical Significance: Highlights the need for early suspicion of
opportunistic infections in immunosuppressed MS patients.
▪ Key Takeaway: Timely diagnosis and specialist neurological care are
crucial to limit long-term morbidity and improve outcomes.
👩⚕️ About
the Speaker
Dr. Annabelle Prosser is a rotational resident doctor at the
Royal Surrey County Hospital, UK.
▪ Graduated from Newcastle University Medical School (2024).
▪ Awarded merit for academic excellence during medical training.
▪ Completed international clinical electives in Vietnam and Thailand.
▪ Published work on the UK Foundation Programme platform, recently adapted into
an E-book.
▪ Emerging clinician-researcher with a strong interest in neurology and
infectious complications of immunotherapy.
🔗 Join the Conference
Event: International Conference onNeurology and Neuroscience
📅 Dates: March 23–25, 2026
📍 Venue: Singapore & Online
🌐 Website: https://neurocareconference.com/
#NeurologyConference #Neuroscience2026 #MultipleSclerosis
#Neuroimmunology #Ocrelizumab #CaseReport #CNSInfections #ClinicalNeurology #NeuroResearch #MedicalConference #SingaporeConference #BrainHealth #NeuroCare2026 #HealthcareInnovation
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