Unraveling Alzheimer’s Disease Progression Through Spatial Single-Cell Technologies

Presenter: Prof. Jiaqian Wu (University of Texas, United States)
Presentation Type: Oral Presentation (In-Person & Online)
Title: Spatial transcriptomics and snRNA-seq unravel cell–cell interactions and signaling pathways in the entorhinal cortex driving Alzheimer’s disease initiation and progression

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🔬 Presentation Highlights

• Research Focus: Decoding the earliest molecular and cellular events that trigger Alzheimer’s disease (AD) using cutting-edge spatial and single-cell sequencing technologies.

• Why the Entorhinal Cortex?: As one of the first brain regions affected in AD, the entorhinal cortex plays a central role in disease onset and pathological spread.

• Advanced Methodology:
  ∙ True single-cell spatial transcriptomics across healthy, early, mid, and late AD stages
  ∙ Integrated single-nucleus RNA sequencing (snRNA-seq) for precise validation of cell-type–specific changes

• Key Findings:
  ∙ Identification of dynamic, stage-dependent transcriptional programs in neurons and glial populations
  ∙ Early and robust astrocyte–neuron communication networks associated with neuronal vulnerability
  ∙ Spatially resolved ligand–receptor signaling pathways influencing synaptic integrity and cellular homeostasis

• Mechanistic Insight: Astrocytes emerge as critical regulators of early AD pathology, actively shaping the neurodegenerative microenvironment.

• Translational Impact:
  ∙ Discovery of astrocyte-enriched early-stage gene signatures
  ∙ Identification of potential molecular targets for early therapeutic intervention in Alzheimer’s disease

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👩‍🔬 About the Speaker

Prof. Jiaqian Wu is a UTHealth Houston Distinguished Professor at the University of Texas McGovern Medical School.

• PhD from Baylor College of Medicine, leading the NIH Mammalian Gene Collection initiative

• Postdoctoral training at Yale University and Stanford University

• Internationally recognized expert in neurodegeneration, neurotrauma, and neural regeneration

• Author of highly influential research with 25,000+ citations worldwide

• Honors include the NIH Pathway to Independence (K99/R00) Award and the Senator Lloyd and B.A. Bentsen Investigator Award

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🔗 Join the Conference
Event: International Conference on Neurology and Neuroscience
📅 March 23–25, 2026
📍 Singapore & Online
🧬 Abstract Submission: https://neurocareconference.com/abstract-submission

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